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Patrick Sung Selected Research

Cruciform DNA (Holliday Junctions)

1/2014Multifaceted role of the Topo IIIα-RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection.
5/2013Role of replication protein A in double holliday junction dissolution mediated by the BLM-Topo IIIα-RMI1-RMI2 protein complex.
10/2007Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex.

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Patrick Sung Research Topics

Disease

32Neoplasms (Cancer)
01/2022 - 05/2003
15Genomic Instability
01/2022 - 11/2007
6Bloom Syndrome
01/2022 - 10/2006
5Fanconi Anemia (Fanconi's Anemia)
12/2020 - 03/2010
5Breast Neoplasms (Breast Cancer)
01/2019 - 07/2012
4Chromosome Breakage
07/2017 - 10/2008
3Ataxia Telangiectasia (Louis Bar Syndrome)
01/2022 - 10/2008
3Chromosome Aberrations (Chromosome Abnormalities)
01/2020 - 03/2010
3Bone Marrow Failure Disorders
12/2019 - 05/2006
3Chromosomal Instability (Chromosome Stability)
09/2009 - 02/2006
2Rothmund-Thomson Syndrome (Syndrome, Rothmund-Thomson)
09/2009 - 02/2006
1Leiomyoma (Uterine Fibroids)
01/2022
1Glioma (Gliomas)
12/2021
1Glioblastoma (Glioblastoma Multiforme)
12/2021
1Infections
10/2019
1Genetic Translocation (Chromosomal Translocation)
01/2019
1Xeroderma Pigmentosum (Kaposi's Disease)
02/2016
1Skin Neoplasms (Skin Cancer)
02/2016
1Hypersensitivity (Allergy)
02/2016
1Colorectal Neoplasms (Colorectal Cancer)
03/2014
1Systemic Lupus Erythematosus (Libman-Sacks Disease)
10/2012
1DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes)
10/2012
1Autoimmune Diseases (Autoimmune Disease)
10/2012
1Prostatic Neoplasms (Prostate Cancer)
10/2012
1Chromosome Fragility
02/2012
1Werner Syndrome (Werner's Syndrome)
09/2009
1Premature Aging
09/2009

Drug/Important Bio-Agent (IBA)

21DNA (Deoxyribonucleic Acid)IBA
01/2022 - 05/2006
14Proteins (Proteins, Gene)FDA Link
01/2022 - 06/2004
7Rad51 RecombinaseIBA
01/2022 - 11/2007
6DNA HelicasesIBA
01/2020 - 05/2003
3RNA (Ribonucleic Acid)IBA
01/2022 - 07/2017
3Phosphotransferases (Kinase)IBA
01/2022 - 01/2019
3A-Form DNA (A-DNA)IBA
11/2015 - 10/2008
3Cruciform DNA (Holliday Junctions)IBA
01/2014 - 10/2007
2Mitomycin (Mitomycin-C)FDA LinkGeneric
01/2022 - 01/2020
2Biological ProductsIBA
01/2022 - 01/2019
2Poly(ADP-ribose) Polymerase InhibitorsIBA
01/2022 - 01/2019
2olaparibIBA
01/2022 - 01/2022
2Mediator ComplexIBA
01/2022 - 07/2015
2Pharmaceutical PreparationsIBA
12/2021 - 01/2021
2CamptothecinIBA
01/2020 - 03/2010
2RecQ HelicasesIBA
01/2019 - 09/2009
21,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA
01/2018 - 02/2016
2ChromatinIBA
11/2015 - 03/2010
2trioctyl phosphine oxide (TOPO)IBA
09/2010 - 05/2006
1Biomarkers (Surrogate Marker)IBA
01/2022
1Bloom syndrome proteinIBA
01/2022
1talazoparibIBA
01/2022
1Immune Checkpoint ProteinsIBA
01/2022
1Hydroxyurea (Hydrea)FDA LinkGeneric
01/2022
1CrizotinibIBA
12/2021
1navitoclaxIBA
12/2021
1Neutralizing AntibodiesIBA
12/2021
1Fanconi Anemia Complementation Group D2 ProteinIBA
12/2020
1cyclic guanosine monophosphate-adenosine monophosphateIBA
10/2019
1Poly (ADP-Ribose) Polymerase-1IBA
01/2019
1Phosphatidylinositols (Phosphatidylinositol)IBA
01/2019
1MicroRNAs (MicroRNA)IBA
01/2019
1EndonucleasesIBA
02/2016
1Replication Protein AIBA
07/2015
1Thymine DNA GlycosylaseIBA
11/2014
1MethyltransferasesIBA
03/2014
1Telomerase (Telomerase Reverse Transcriptase)IBA
10/2013
1telomerase RNA (bTR)IBA
05/2013
1AutoantibodiesIBA
10/2012
1Doxorubicin (Adriamycin)FDA LinkGeneric
10/2012
1Antinuclear AntibodiesIBA
10/2012
1Histones (Histone)IBA
03/2010
1DNA-Activated Protein KinaseIBA
10/2008
1Proteasome Endopeptidase Complex (Proteasome)IBA
10/2008
1Type I DNA Topoisomerases (Topoisomerase I)IBA
10/2008
1Methyl MethanesulfonateIBA
10/2008
1Peptides (Polypeptides)IBA
10/2008
1Saccharomyces cerevisiae ProteinsIBA
11/2007
1NucleoproteinsIBA
11/2004

Therapy/Procedure

6Therapeutics
01/2022 - 10/2012
2Drug Therapy (Chemotherapy)
01/2019 - 03/2014
1Immunotherapy
01/2022
1Radiotherapy
12/2021
1Aftercare (After-Treatment)
03/2014